The UK will adopt an official definition of antisemitism meaning perpetrators will be "called out on it", Theresa May will say in a speech on Monday.
The wording put forward by the International Holocaust Remembrance Alliance will be used by police, councils, universities and public bodies. It defines the hatred as "a certain perception of Jews, which may be expressed as hatred toward Jews."
It adds: "Rhetorical and physical manifestations of anti-Semitism are directed toward Jewish or non-Jewish individuals and/or their property, toward Jewish community institutions and religious facilities."
The organisation says it hopes the wording will be adopted globally.
It is already used in 31 countries including the USA, Israel, France and Germany. The group says having a "legally binding working definition" gives countries the "political tools" to deal with anti-Jewish hate.
Downing Street the wording would mean people could no longer get away with antisemitism because it was poorly defined or because different bodies used different definitions.
The Prime Minister will say: "There will be one definition of anti-Semitism - in essence, language or behaviour that displays hatred towards Jews because they are Jews - and anyone guilty of that will be called out on it."
She will add: "It is unacceptable that there is anti-Semitism in this country. It is even worse that incidents are reportedly on the rise."
Communities Secretary Sajid Javid said anti-Semitism must be seen as "an attack on the identity of people who live, contribute and are valued in our society".
"There can be no excuses for anti-Semitism or any other form of racism or prejudice," he said.
"Crimes must always be reported, and the law enforced, but we also want to create an environment that prevents hate crime from happening in the first place."
The announcement comes after a man who subjected Jewish Labour MP Luciana Berger to online abuse was jailed for two years last week.
Labour leader Jeremy Corbyn, who has faced accusations of being soft on antisemitism, welcomed the move. His spokesman said hatred towards Jews was "as repugnant and unacceptable as any other form of racism".
