At least 60 people have been killed in a suicide attack on a military compound in Yemen on Monday.

ISIS have claimed responsibility for the bombing after a man drove a car laden with explosives into a compound run by pro-government local militias in Aden in one of the deadliest attacks in the southern Yemeni port city.

An official from Medecins Sans Frontieres said at least 60 others were brought into a nearby hospital run by the medical charity in Aden's Mansoura district.

A security source said the attack targeted a school compound where conscripts of the Popular Committees, forces allied to the President Abd-Rabbu Mansour Hadi, were gathered for breakfast.

The blast rocked the area and sent debris flying, sending residents fleeing, one witness said.

Islamist militants have exploited an 18-month-old civil war between the Houthis and Hadi's supporters and launched a series of attacks targeting senior officials, religious figures, security forces and compounds of the Saudi-led Arab military coalition which supports Hadi.

Around 2.5 million Yemenis have been displaced by the conflict.