'Jesus Is Muslim' billboards have been erected around Columbus, Ohio.
They have ruffled the feathers of some Christians, who say they are particularly "insensitive" as they appear during the season of Lent.
The billboards have straplines like "Jesus is Muslim", "Mohammed is in the bible" and "Muslims love Jesus too".
They have been paid for by the group behind the website Ask-A-Muslim.com, which seeks to explain the Muslim faith.
Coach Dave Daubenmire of Pass the Salt Ministries, the Reverend Rusty Thomas of Operation Save America, and Pastor Bill Dunfee of New Beginnings Church in Warsaw, Ohio, are among local Christians staging a prayer vigil in protest on Saturday.
"Although we support the Islamic community's right to free speech, as well as their right to post messages on billboards, we do not support the hi-jacking of the name of Jesus Christ in their attempt to lure uninformed Christians into their religion," Daubenmire said.
"Although Islam honours Jesus as a prophet, they do not believe that He is the risen Son of God. During this most Holy Lenten season we find the messages on the billboards to be insensitive, dishonest and deserving of a response from concerned Christians. We will be on the streets to proclaim Jesus is not Muslim but Jesus is Lord."