The New England Patriots will be taking on the Buffalo Bills in upstate New York on Sunday as the NFL 2013 regular season Week 1 gets underway. The Patriots will be favorites to win this one but the Bills have home advantage and will be hoping to pull off a shock.

The game is scheduled to start at 1 p.m. ET and can be watched online through live stream via the link provided below.

Rookie quarterback E.J. Manuel will be up against three-time Super Bowl champ Tom Brady on Sunday afternoon at Ralph Wilson Stadium. After missing most of the preseason recovering from a minor knee surgery Manuel begins his NFL career against one of the best quarterbacks in recent times.

The Bills hope the Florida State standout can be inspirational this year and lead them into the playoffs.

The Patriots have had a tough offseason after now-released tight end Aaron Hernandez was charged with murder, and Rob Gronkowski is still recovering from a number of injuries. In addition, Wes Welker left on bitter terms.

That leaves Brady without three good receiving threats, but the Patriots will look to undrafted receiver Kenbrell Thompkins, and rookie Zach Sudfeld.

The Bills meanwhile welcomed new head coach Doug Marrone from Syracuse and will hope that his ability to work with young passers can get the best out of Manuel.

The New England Patriots will be taking on the Buffalo Bills from 1 p.m. ET and will be broadcast on TV on CBS. For those hoping to catch the game online through live stream, they can watch online by clicking here.